Methanesulfonic Acid → HCID 86754643, compound

HRID 1740408Notes

Reaction equation

HRID 1740408 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH2:16][C@H:15]([CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][O:27][CH3:28])[CH2:21][CH2:20]3)[C:14]2=[O:29])=[CH:9][CH:8]=1>C(OCC)(=O)C>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH2:16][C@H:15]([CH2:18][N:19]3[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][O:27][CH3:28])[CH2:23][CH2:24]3)[C:14]2=[O:29])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 9892249MS-377

Product 1

HCID 86754643HCID 86754643, compoundYield 82.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 480 mg of methanesulfonic acid in 5 mL of ethyl acetate was added to a solution of 880 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 15 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 1127 mg of the title compound.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-23cad752b9e64390833c7aca00b19962
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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