D-Tartaric acid → HCID 86754645, compound

Participants

Reaction Steps

A solution of D-tartaric acid (450 mg) in ethanol (6 ml) was added dropwise at an outer temperature between 50 and 60° C. to a solution of 1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone (1056mg) in ethanol (6ml). The reaction mixture was allowed to stand for cooling and the solid material thus precipitated was collected by filtration. The solid material was further crystallized in 10 ml of ethanol to obtain 372 mg of the title compound. Enantiomer excess: 97% ee

Provenance & Evidence