HRID1740413

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID439655

未命名化合物

反应SMILES：COCCN1CCN(CC2CCN(c3ccc(Cl)cc3)C2=O)CC1

HCID4913209

未命名化合物

PRODUCTS

产物

反应SMILES：COCCN1CCN(C[C@H]2CCN(c3ccc(Cl)cc3)C2=O)CC1.O=C(O)[C@@H](O)[C@H](O)C(=O)O.O=C(O)[C@@H](O)[C@H](O)C(=O)O

HCID86754645

未命名化合物

收率 38.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

A solution of D-tartaric acid (450 mg) in ethanol (6 ml) was added dropwise at an outer temperature between 50 and 60° C. to a solution of 1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone (1056mg) in ethanol (6ml). The reaction mixture was allowed to stand for cooling and the solid material thus precipitated was collected by filtration. The solid material was further crystallized in 10 ml of ethanol to obtain 372 mg of the title compound. Enantiomer excess: 97% ee

WORKUP

后处理

temperaturefor cooling
customthe solid material thus precipitated
filtrationwas collected by filtration
customThe solid material was further crystallized in 10 ml of ethanol

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-9788babb7da54095b80391d0a3333c25
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05969138
来源说明: uspto-grants-1999_10

反应SMILES

[C:1]([OH:10])(=[O:9])[C@H:2]([C@@H:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][CH:20]([CH2:23][N:24]3[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:26][CH2:25]3)[C:19]2=[O:34])=[CH:14][CH:13]=1>C(O)C>[C:6]([C@H:4]([C@@H:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[C:6]([C@H:4]([C@@H:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][C@H:20]([CH2:23][N:24]3[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][O:32][CH3:33])[CH2:28][CH2:29]3)[C:19]2=[O:34])=[CH:14][CH:13]=1