Succinic Acid → HCID 86754646, compound

HRID 1740414Notes

Reaction equation

HRID 1740414 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][CH2:19][C@H:18]([CH2:21][N:22]3[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][O:30][CH3:31])[CH2:24][CH2:23]3)[C:17]2=[O:32])=[CH:12][CH:11]=1>C(O)C>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][CH2:19][C@H:18]([CH2:21][N:22]3[CH2:23][CH2:24][N:25]([CH2:28][CH2:29][O:30][CH3:31])[CH2:26][CH2:27]3)[C:17]2=[O:32])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 9892249MS-377

Product 1

HCID 86754646HCID 86754646, compoundYield 24.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 591 mg of succinic acid in 20 mL of ethanol was added to a solution of 880 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 20 mL of ethanol. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 356 mg of the title compound.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

Sources & evidence

ORD record
ord-3bb06041a79a45b7a7de032453fec4c5
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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