Fumaric Acid → HCID 86754647, compound

HRID 1740415Notes

Reaction equation

HRID 1740415 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:16][CH2:15]3)[C:9]2=[O:24])=[CH:4][CH:3]=1.[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29]>O.C(O)C>[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29].[C:25]([OH:32])(=[O:31])/[CH:26]=[CH:27]/[C:28]([OH:30])=[O:29].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]3[CH2:15][CH2:16][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:18][CH2:19]3)[C:9]2=[O:24])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 9892249MS-377

Product 1

HCID 86754647HCID 86754647, compoundYield 89.8%

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

Into 62 mL of 13% water-ethanol were suspended 5.00 g of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone and 3.30 g of fumaric acid. After making it homogeneous by heating under reflux, the solution was cooled. The precipitated solid was filtered and dried to give 7.45 g of the title compound.

Workup

  1. temperatureby heating
  2. temperatureunder reflux
  3. temperaturethe solution was cooled
  4. filtrationThe precipitated solid was filtered
  5. customdried

Sources & evidence

ORD record
ord-624079f5019e44d79dbaa7c88fd3b10c
Source dataset
uspto-grants-1999_10
Patent number
US05969138

Reaction notes

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