3-Amino-5,5-dimethyl-2-cyclohexen-1-one → HCID 70298834, compound

HRID 1740432Notes

Reaction equation

HRID 1740432 reaction equation
[NH2:1][C:2]1[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4](=[O:10])[CH:3]=1.CO[CH:13](OC)[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([S:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:23])=[O:22])[CH:15]=1>>[C:24]1([S:21]([C:16]2[CH:15]=[C:14]([CH:13]3[C:3]4[C:4](=[O:10])[CH2:5][C:6]([CH3:9])([CH3:8])[CH2:7][C:2]=4[NH:1][C:2]4[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4](=[O:10])[C:3]3=4)[CH:19]=[CH:18][C:17]=2[Cl:20])(=[O:22])=[O:23])[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 1366803-Amino-5,5-dimethyl-2-cyclohexen-1-oneHCID 22117818HCID 22117818, compound

Product 1

HCID 70298834HCID 70298834, compound

Procedure

Reaction of 3-amino-5,5-dimethyl-2-cyclohexen-1-one with 4-chloro-3-phenylsulphonylbenzaldehyde dimethyl acetal in an analogous manner to that described in Example 1 gave 9-[3-benzenesulphonyl-4-chlorophenyl]-3,4,6,7,9,10-hexahydro-3,3,6,6-tetramethyl-1,8(2H,5H)-acridinedione. Crystallization from dimethylformamide/water gave a yellow crystalline solid of melting point 252-254° C. (decomposition).

Sources & evidence

ORD record
ord-0df284faaa3e485f8c44badbfedd9c3d
Source dataset
uspto-grants-1999_10
Patent number
US05969139

Reaction notes

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