反应详情

A reactor containing 38.6 g (0.11 mol) of 3-[(ethoxycarbonyl)amino]-6-(phenylmethoxy)benzofuran-2-carboxylic acid under nitrogen is immersed in an oil bath at 185-190° C. for 5 minutes. The residue is then taken up in ethyl acetate and the solution is then washed with an aqueous potassium hydrogencarbonate solution and then with a saturated aqueous sodium chloride solution. The organic phase is then dried over sodium sulphate, the solvent is evaporated and the residue is purified on a silica column with a mixture containing 20% of ethyl acetate in cyclohexane. After trituration in diisopropyl ether, 25 g of product are obtained.

1. washthe solution is then washed with an aqueous potassium hydrogencarbonate solution
2. dry with materialThe organic phase is then dried over sodium sulphate
3. customthe solvent is evaporated
4. customthe residue is purified on a silica column with a mixture
5. additioncontaining 20% of ethyl acetate in cyclohexane