Hydrochloric Acid → HCID 21838732, compound

Participants

Reaction Conditions

Reaction Steps

92 ml of a 10% ethanolic potassium hydroxide solution are added to a solution of 31.4 g (0.101 mol) of methyl 3-[(ethoxycarbonyl)amino]-6-methoxybenzo[b]thiophene-2-carboxylate in 230 ml of ethanol. The mixture is heated at 60° C. for 10 minutes and is then poured onto ice-cold water. The mixture is acidified by addition of a 6N hydrochloric acid solution and the precipitate formed is filtered off, rinsed with water and dried under reduced pressure. The solid is triturated in ethanol. 22.8 g of product are recovered.

Provenance & Evidence