Hydrochloric Acid → HCID 21838732, compound

HRID 1740499Notes

Reaction equation

HRID 1740499 reaction equation
[OH-].[K+].[CH2:3]([O:5][C:6]([NH:8][C:9]1[C:10]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:11]=2[S:12][C:13]=1[C:14]([O:16]C)=[O:15])=[O:7])[CH3:4].Cl>C(O)C>[CH2:3]([O:5][C:6]([NH:8][C:9]1[C:10]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:11]=2[S:12][C:13]=1[C:14]([OH:16])=[O:15])=[O:7])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 21838739HCID 21838739, compound

Product 1

HCID 21838732HCID 21838732, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

92 ml of a 10% ethanolic potassium hydroxide solution are added to a solution of 31.4 g (0.101 mol) of methyl 3-[(ethoxycarbonyl)amino]-6-methoxybenzo[b]thiophene-2-carboxylate in 230 ml of ethanol. The mixture is heated at 60° C. for 10 minutes and is then poured onto ice-cold water. The mixture is acidified by addition of a 6N hydrochloric acid solution and the precipitate formed is filtered off, rinsed with water and dried under reduced pressure. The solid is triturated in ethanol. 22.8 g of product are recovered.

Workup

  1. additionis then poured onto ice-cold water
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washrinsed with water
  5. customdried under reduced pressure
  6. customThe solid is triturated in ethanol
  7. custom22.8 g of product are recovered

Sources & evidence

ORD record
ord-b3acc13d3c1749f19660bfefccba2738
Source dataset
uspto-grants-1999_10
Patent number
US05969146

Reaction notes

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