Hydrochloric Acid → HCID 18700149, compound

HRID 1740587Notes

Reaction equation

HRID 1740587 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH:4]=1.Cl.[CH3:20]O>>[ClH:1].[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH3:20])=[O:11])=[C:5]([O:13][CH2:14][C:15]([F:16])([F:17])[F:18])[CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 70059445HCID 70059445, compound

Product 1

HCID 18700149HCID 18700149, compound

Procedure

Into a stirred solution of 4-amino-2-(2,2,2-trifluoroethoxy)phenylacetic acid hydrochloride (0.95 g, 3.5 mmol) from Step 6 above in MeOH (25 mL) at 0° C. was bubbled HCl gas for 10 min. The resulting solution was warmed to ambient temperature and stirred for 14 h. The solvent was removed under reduced pressure to give methyl 4-amino-2-(2,2,2-trifluoroethoxy)phenylacetate hydrochloride as a solid (HPLC retention time=5.6 min (method A)).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-5ee38eab764140428142598beb4ce303
Source dataset
uspto-grants-1999_10
Patent number
US05968938

Reaction notes

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