HCID 21837219, compound → 1-(3-Ethylphenyl)piperazine

HRID 1740620Notes

Reaction equation

HRID 1740620 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][CH3:21])[CH:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O>CCOC(C)=O>[CH2:20]([C:16]1[CH:15]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=[CH:18][CH:17]=1)[CH3:21]

Participants

3

Reactant 1

HCID 21837219HCID 21837219, compound

Product 1

HCID 199114731-(3-Ethylphenyl)piperazine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

0.037 g (0.128 mmol) 1-Boc-4-(3-ethylphenyl)-piperazine from the previous step was dissolved in 10 mL EtOAc and cooled to 0° C. using an ice bath. HCl gas was then bubbled through the reaction for 10 min, followed by an additional 10 min of stirring. The reaction was warmed to ambient temperature and the solvent removed in vacuo. The residue was taken up in 10 mL CHCl3 that had been previously saturated with NH3 gas, the solid NH4Cl filtered, and the solvent removed to give 1-(3-ethylphenyl)piperazine as the free base.

Workup

  1. customHCl gas was then bubbled through the reaction for 10 min
  2. temperatureThe reaction was warmed to ambient temperature
  3. customthe solvent removed in vacuo
  4. filtrationthe solid NH4Cl filtered
  5. customthe solvent removed

Sources & evidence

ORD record
ord-5dd28b3b4fa74fa1818ce9ff72830c03
Source dataset
uspto-grants-1999_10
Patent number
US05968938

Reaction notes

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