Pyrazole → 3-(1H-pyrazol-1-yl)propanoic acid

HRID 1740669Notes

Reaction equation

[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.Cl[CH2:7][CH2:8][C:9]([O:11]CC)=[O:10]>>[N:1]1([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:4][CH:3]=[N:2]1

Participants

Reactant 2

HCID 1048Pyrazole

HCID 69341Ethyl 3-chloropropionate

Product 1

HCID 10929723-(1H-pyrazol-1-yl)propanoic acid

Procedure

6.8 g of pyrazole were reacted with ethyl 3-chloropropionate as in Example 3 and processed further in a similar manner. 11.8 g ([lacuna] of theory) of 3-(N-pyrazolyl)propionic acid are obtained as a white powder of m.p. 70° C.

Sources & evidence

ORD record: ord-57181e7414cd40bb83cab9534749d221
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972064

Reaction notes

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