Tacrine → HCID 86754655, compound

HRID 1740682Notes

Reaction equation

HRID 1740682 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[C:7]([NH2:15])[C:8]3[CH2:14][CH2:13][CH2:12][CH2:11][C:9]=3[N:10]=2)[CH:6]=1.[CH3:16][C@@H:17]([N:25]([CH2:27][C:28]#[CH:29])[CH3:26])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1.C([O-])(=O)C=C>C(O)C.C(OCC)(=O)C.CCCCCC>[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[C:7]([NH2:15])[C:8]3[CH2:14][CH2:13][CH2:12][CH2:11][C:9]=3[N:10]=2)[CH:6]=1.[CH3:16][C@@H:17]([N:25]([CH2:27][C:28]#[CH:29])[CH3:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

7

Reactant 3

HCID 1935TacrineHCID 25188AcrylateHCID 26757Selegiline

Product 1

HCID 86754655HCID 86754655, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

tacrine and selegiline base are dissolved in ethanol. The solution obtained is added to a solution of acrylate adhesive (e.g. Duro-Tak® such as Duro-Tak® 326-1753; National Starch & Chemicals) in ethyl acetate and n-hexane and, optionally, it can be mixed with further auxiliary agents. Subsequently, the solution is applied by means of a doctor blade onto a siliconised polyester film as peel-off film (e.g. Hostaphan®, Hoechst) with a wet layer thickness of 450 μm and dried for 1 hour at 50° C. The dried layer is laminated with a polyester film (or any other suitable covering film). Using a punch, TTS with a surface area of 10, 20, 30 and 40 cm2 are punched from the laminate.

Workup

  1. customThe solution obtained
  2. additionoptionally, it can be mixed with further auxiliary agents
  3. customdried for 1 hour at 50° C

Sources & evidence

ORD record
ord-59902cb3c56f4f5798e0e0854b0588fc
Source dataset
uspto-grants-1999_10
Patent number
US05972376

Reaction notes

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