Hydrochloric Acid → 16-Aminohexadecan-1-ol

Participants

Reaction Steps

To a suspension of 0.65 g of 16-methoxymethoxyhexadecylamine in 40 ml of methanol was added 1 ml of conc. hydrochloric acid and the mixture was heated under reflux for one hour. The reaction solution was distilled under reduced pressure. The residue was diluted with a 1N aqueous solution of sodium hydroxide, extracted with chloroform, dried over anhydrous sodium sulfate and distilled under reduced pressure to afford the title compound as a colorless crystal.

Provenance & Evidence