Hydrochloric Acid → 16-Aminohexadecan-1-ol

HRID 1740785Notes

Reaction equation

HRID 1740785 reaction equation
COC[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21].Cl>CO>[NH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][OH:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21833206HCID 21833206, compound

Product 1

HCID 1327223316-Aminohexadecan-1-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 0.65 g of 16-methoxymethoxyhexadecylamine in 40 ml of methanol was added 1 ml of conc. hydrochloric acid and the mixture was heated under reflux for one hour. The reaction solution was distilled under reduced pressure. The residue was diluted with a 1N aqueous solution of sodium hydroxide, extracted with chloroform, dried over anhydrous sodium sulfate and distilled under reduced pressure to afford the title compound as a colorless crystal.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for one hour
  3. distillationThe reaction solution was distilled under reduced pressure
  4. additionThe residue was diluted with a 1N aqueous solution of sodium hydroxide
  5. extractionextracted with chloroform
  6. dry with materialdried over anhydrous sodium sulfate
  7. distillationdistilled under reduced pressure

Sources & evidence

ORD record
ord-77dc99d637e049c98f478aeb8dc0d2aa
Source dataset
uspto-grants-1999_10
Patent number
US05972943

Reaction notes

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