Potassium Hydroxide → 1-Isopropylpiperazine

HRID 1740790Notes

Reaction equation

HRID 1740790 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([CH:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]1)(=O)C.[OH-].[K+]>CO>[CH:10]([N:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 187964191-[4-(Propan-2-yl)piperazin-1-yl]ethan-1-one

Product 1

HCID 780131-IsopropylpiperazineYield 105.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 7.26 g of 1-acetyl-4-isopropylpiperazine, 100 ml of methanol and 10 g of potassium hydroxide was heated under reflux for 17 hours. After the solvent was distilled off, water and chloroform were added to perform extraction with chloroform and the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to afford 5.78 g of the title compound as an oily substance.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 17 hours
  3. distillationAfter the solvent was distilled off
  4. additionwater and chloroform were added
  5. extractionextraction with chloroform
  6. dry with materialthe extract was dried over anhydrous magnesium sulfate
  7. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-93506c81b4994fe99c541d2a852aa260
Source dataset
uspto-grants-1999_10
Patent number
US05972943

Reaction notes

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