L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- → HCID 21833535, Verbindung
Reaktionsgleichung
Cl[C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1.[NH2:16][CH:17]([CH2:27][O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:18]([N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])=[O:19].C(OC(N[C@H](C(O)=O)COCC1C=CC=CC=1)=O)(C)(C)C>C(N(CC)CC)C>[CH2:29]([O:28][CH2:27][CH:17]([NH:16][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1)[C:18]([N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])=[O:19])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 150 °C
Versuchsvorschrift
A mixture of 4-chloro-5,6-dimethyl-2-phenylpyrimidine (1.8 g), 2-amino-3-benzyloxy-N,N-dipropylpropanamide (4.6 g), which is prepared from N-(tert-butoxycarbonyl)-O-benzylserine, and triethylamine (1.7 g) is stirred at 150° C. for 5 hours. The reaction mixture is treated in the same manner as in Example 1 to give 3-benzyloxy-2-(5,6-dimethyl-2-phenyl-4-pyrimidinylamino)-N,N-dipropylpropanamide (3.5 g) as an oily product.
Aufarbeitung
- additionThe reaction mixture is treated in the same manner as in Example 1
Quellen und Nachweise
- ORD-Eintrag
- ord-d758a28203d44168a1915afe48584c5f
- Quelldatensatz
- uspto-grants-1999_10
- Patentnummer
- US05972946
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