HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- → 3-benzyloxy-2-(5,6-dimethyl-2-phenyl-4-pyrimidinylamino)-N,N-dipropylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)- | HCID 90234 | — |
| Reactant | 4-Chloro-5,6-dimethyl-2-phenylpyrimidine | HCID 13487935 | — |
| Reactant | HCID 21833470 | HCID 21833470 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-benzyloxy-2-(5,6-dimethyl-2-phenyl-4-pyrimidinylamino)-N,N-dipropylpropanamide | HCID 21833535 | 92.3% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
A mixture of 4-chloro-5,6-dimethyl-2-phenylpyrimidine (1.8 g), 2-amino-3-benzyloxy-N,N-dipropylpropanamide (4.6 g), which is prepared from N-(tert-butoxycarbonyl)-O-benzylserine, and triethylamine (1.7 g) is stirred at 150° C. for 5 hours. The reaction mixture is treated in the same manner as in Example 1 to give 3-benzyloxy-2-(5,6-dimethyl-2-phenyl-4-pyrimidinylamino)-N,N-dipropylpropanamide (3.5 g) as an oily product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972946 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-d758a28203d44168a1915afe48584c5f |
| Source note | uspto-grants-1999_10 |