4-Chloro-6-methyl-2-phenylpyrimidine → HCID 21833464, compound

HRID 1740853Notes

Reaction equation

HRID 1740853 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.[NH2:15][CH2:16][C:17]([N:19]([CH3:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:18].ClC1C(C)=C(C)N=C(C2C=CC=CC=2)N=1.NCC(N(CCC)CCC)=O>>[CH3:8][C:6]1[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=[C:2]([NH:15][CH2:16][C:17]([N:19]([CH3:26])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:18])[CH:7]=1

Participants

5

Reactant 4

HCID 5982554-Chloro-6-methyl-2-phenylpyrimidineHCID 117688992-amino-N-methyl-N-phenylacetamideHCID 127424812-amino-N,N-dipropyl-acetamideHCID 134879354-Chloro-5,6-dimethyl-2-phenylpyrimidine

Product 1

HCID 21833464HCID 21833464, compound

Procedure

The same procedures as Example 1 are repeated except that 4-chloro-6-methyl-2-phenylpyrimidine and 2-amino-N-methyl-N-phenylacetamide are used instead of 4-chloro-5,6-dimethyl-2-phenylpyrimidine and 2-amino-N,N-dipropylacetamide, respectively. The product thus obtained is recrystallized from isopropanol to give the desired compound, m.p. 134-136° C.

Workup

  1. customThe product thus obtained
  2. customis recrystallized from isopropanol

Sources & evidence

ORD record
ord-4967eb9c61074c8bb7fc8bfb707b2e8c
Source dataset
uspto-grants-1999_10
Patent number
US05972946

Reaction notes

Loading…