反应详情

温度

90 °C

A mixture of 2-(6-methyl-2-phenyl-4-pyrimidinylamino)-N-methyl-N-phenylacetamide (1.0 g) obtained in Example 88, N-chlorosuccinimide (0.44 g) and acetic acid (15 ml) is heated with stirring at 90° C. for three hours, and the reaction mixture is concentrated under reduced pressure. To the residue is added ice-water (30 ml) with stirring, and the precipitates are collected by filtration, washed with water, and recrystallized from isopropanol to give the desired compound (1.1 g), m.p. 154-155° C.

1. temperatureis heated
2. concentrationthe reaction mixture is concentrated under reduced pressure
3. additionTo the residue is added ice-water (30 ml)
4. stirringwith stirring
5. filtrationthe precipitates are collected by filtration
6. washwashed with water
7. customrecrystallized from isopropanol