反应详情

温度

150 °C

A mixture of 4-chloro-5,6,7,8-tetrahydro-2-phenylquinazoline (1.0 g), 2-amino-N,N-dipropylacetamide (0.78 g) and triethylamine (0.5 g) is refluxed with stirring at 150° C. for three hours. To the reaction mixture are added water and chloroform, and the chloroform layer is separated, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform), and recrystallized from a mixture of diethyl ether and n-hexane to give the desired compound (1.3 g), m.p. 87-88° C.

1. temperatureis refluxed
2. customthe chloroform layer is separated
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe residue is purified by silica gel column chromatography (eluent; chloroform)
6. customrecrystallized from a mixture of diethyl ether and n-hexane