反应详情

4-Carboxy-2-acetylaminopyridine (3.4 g, 19 mmol) was dissolved in methanol/benzene (100 mL, 1:1). TMS-diazomethane was added (1M, Aldrich) with cooling until the yellow color just persisted, then the solvent was removed under reduced pressure. The product was purified by silica gel column chromatography (50/50 hexane/ethyl acetate) and 3.0 g of product was recovered.

1. temperaturewith cooling until the yellow color
2. customthe solvent was removed under reduced pressure
3. customThe product was purified by silica gel column chromatography (50/50 hexane/ethyl acetate) and 3.0 g of product
4. customwas recovered