HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → Methyl 2-acetamidoisonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 2-Acetamidopyridine-4-carboxylic acid | HCID 3774466 | — |
| Solvent | Benzene methanol | HCID 21927730 | — |
| Product | Methyl 2-acetamidoisonicotinate | HCID 22185175 | — |
Reaction Steps
4-Carboxy-2-acetylaminopyridine (3.4 g, 19 mmol) was dissolved in methanol/benzene (100 mL, 1:1). TMS-diazomethane was added (1M, Aldrich) with cooling until the yellow color just persisted, then the solvent was removed under reduced pressure. The product was purified by silica gel column chromatography (50/50 hexane/ethyl acetate) and 3.0 g of product was recovered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972975 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-5841a4b889fc4ec4832020a9bd18915c |
| Source note | uspto-grants-1999_10 |