Acetic Anhydride → HCID 9834118, compound

HRID 1740952Notes

Reaction equation

HRID 1740952 reaction equation
Cl.Cl.[NH2:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([CH2:11][NH2:12])=[CH:6][N:5]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>CO>[NH2:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([CH2:11][NH:12][C:20](=[O:22])[CH3:21])=[CH:6][N:5]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 9813139HCID 9813139, compound

Product 1

HCID 9834118HCID 9834118, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-amino-5-aminomethyl-4-methylpyridine dihydrochloride (70 mg, 0.333 mmol) in methanol (2 mL) were added triethylamine (93 uL, 0.667 mmol) and acetic anhydride (47 uL, 0.498 mmol). The reaction mixture was stirred for 2 h at room temperature and then evaporated. The residue was chromatographed on silica gel (10% methanol/methylene chloride) to afford pure title compound.

Workup

  1. customevaporated
  2. customThe residue was chromatographed on silica gel (10% methanol/methylene chloride)

Sources & evidence

ORD record
ord-fd86ad5d51264bd38316c9ae33d4af48
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Reaction notes

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