Potassium Hydroxide → HCID 9898925, compound

HRID 1740972Notes

Reaction equation

HRID 1740972 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][N:11]2C(C)=CC=C2C)[N:5]=[C:4]([N:18]2C(C)=CC=C2C)[CH:3]=1.Cl.NO.[OH-].[K+]>C(O)C.O>[NH2:18][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][NH2:11])[N:5]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 21834428HCID 21834428, compound

Product 1

HCID 9898925HCID 9898925, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

By analogy to Example 56, Step B, 4-methyl-2-(2,5-dimethylpyrrol-1-yl)-6-(3-(2,5-dimethylpyrrol-1-yl)propyl)pyridine was treated with 9.2 equivalents of hydroxylamine hydrochloride and 5.4 equivalents of potassium hydroxide in refluxing ethanol/water to yield 2-amino-6-(3-aminopropyl)-4-methylpyridine.

Sources & evidence

ORD record
ord-6d7990d03eb841a2a463f33ff02f3ad2
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Reaction notes

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