Potassium Hydroxide → HCID 9834486, compound

HRID 1740979Notes

Reaction equation

HRID 1740979 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:5]=[C:4]([N:17]2C(C)=CC=C2C)[CH:3]=1.Cl.NO.[OH-].[K+]>C(O)C.O>[NH2:17][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:5]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 21834452HCID 21834452, compound

Product 1

HCID 9834486HCID 9834486, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

By analogy to Example 56, Step B, 4-methyl-2-(2,5-dimethylpyrrol-1-yl)-6-(3-phenylpropyl)pyridine was treated with 4.6 equivalents of hydroxylamine hydrochloride and 2.8 equivalents of potassium hydroxide in refluxing ethanol/water to yield 2-amino-4-methyl-6-(3-phenylpropyl)pyridine as a yellow oil which spontaneously crystallized.

Sources & evidence

ORD record
ord-9d9cfec191a44259b8b83ac82354a664
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Reaction notes

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