Hydrochloric Acid → HCID 9899427, compound

Participants

Reaction Steps

A mixture of dimethyl (2-(6-amino-4-methyl-2-pyridinyl)ethyl)malonate (34 mg, 0.13 mmol) in 2.0 mL of 2.0 N hydrochloric acid was refluxed for 8 h. After cooling to room temperature, the reaction was extracted with 2×15 mL of dichloromethane and the aqueous phase was concentrated in vacuo to give 17 mg (58% yield) of 4-(6-amino-4-methyl-2-pyridinyl)butanoic acid hydrochloride.

Provenance & Evidence