Hydrochloric Acid → HCID 9899427, compound

HRID 1740992Notes

Reaction equation

HRID 1740992 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH2:8][CH2:9][CH:10](C(OC)=O)[C:11]([O:13]C)=[O:12])[CH:5]=[C:4]([CH3:19])[CH:3]=1.[ClH:20]>>[ClH:20].[NH2:1][C:2]1[N:7]=[C:6]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[C:4]([CH3:19])[CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 53949251HCID 53949251, compound

Product 1

HCID 9899427HCID 9899427, compoundYield 58%

Procedure

A mixture of dimethyl (2-(6-amino-4-methyl-2-pyridinyl)ethyl)malonate (34 mg, 0.13 mmol) in 2.0 mL of 2.0 N hydrochloric acid was refluxed for 8 h. After cooling to room temperature, the reaction was extracted with 2×15 mL of dichloromethane and the aqueous phase was concentrated in vacuo to give 17 mg (58% yield) of 4-(6-amino-4-methyl-2-pyridinyl)butanoic acid hydrochloride.

Workup

  1. temperaturewas refluxed for 8 h
  2. extractionthe reaction was extracted with 2×15 mL of dichloromethane
  3. concentrationthe aqueous phase was concentrated in vacuo

Sources & evidence

ORD record
ord-2e65b94d19d744c8ad21d008116d8e81
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Reaction notes

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