1,2,3,6-Tetrahydro-1-methylpyridine-4-methanol → 1-Acetyl-8bromo-7-(1-methyl-1,2,3,6-tetrahydro-4-pyridyl)methoxy-2,3,4,5-tetrahydro-1H-benzazepine

HRID 1741046Notes

Reaction equation

HRID 1741046 reaction equation
[C:1]([N:4]1[C:10]2[CH:11]=[C:12]([Br:16])[C:13]([OH:15])=[CH:14][C:9]=2[CH2:8][CH2:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2].O[CH2:18][C:19]1[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH:24]=1>>[C:1]([N:4]1[C:10]2[CH:11]=[C:12]([Br:16])[C:13]([O:15][CH2:18][C:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH:20]=3)=[CH:14][C:9]=2[CH2:8][CH2:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 1189211,2,3,6-Tetrahydro-1-methylpyridine-4-methanolHCID 218338021-Acetyl-8-bromo-7-hydroxy-2,3,4,5-tetrahydro-1H-benzazepine

Product 1

HCID 218338141-Acetyl-8bromo-7-(1-methyl-1,2,3,6-tetrahydro-4-pyridyl)methoxy-2,3,4,5-tetrahydro-1H-benzazepine

Procedure

The title compound was prepared from 1-acetyl-8-bromo-7-hydroxy-2,3,4,5-tetrahydro-1H-benzazepine (D25) and 4-(hydroxymethyl)-1-methyl-1,2,3,6-tetrahydropyridine (D1) following the procedure of Description 2.

Sources & evidence

ORD record
ord-b07d0eedd89a492c9b5f43be722ebfe3
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

Loading…