2-(4-Bromo-3-methylphenyl)-5-methyl-1,3,4-oxadiazole → 2,2'-Dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxylic acid

HRID 1741049Notes

Reaction equation

HRID 1741049 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[CH3:14].B([C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]=1[CH3:27])(O)O>>[CH3:27][C:19]1[CH:20]=[C:21]([C:22]([OH:24])=[O:23])[CH:25]=[CH:26][C:18]=1[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[CH3:14]

Participants

3

Reactant 2

HCID 114366932-(4-Bromo-3-methylphenyl)-5-methyl-1,3,4-oxadiazoleHCID 221158924-Borono-3-methylbenzoic acid

Product 1

HCID 218337692,2'-Dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxylic acid

Procedure

The title compound was prepared from 2-(4-bromo-3-methylphenyl)-5-methyl-1,3,4-oxadiazole (EP 0533268 A1) and 4-borono-3-methylbenzoic acid (D33) using a similar procedure to Description 11 as a white solid (31%).

Sources & evidence

ORD record
ord-a62c4f55da3546a38b9f69d5afbfb2eb
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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