反应详情

4-Bromo-3-methylbenzoic hydrazide (D30, 3.06 g, 13 mmol), ethyl acetimidate hydrochloride (2.48 g, 20 mmol) and triethylamine (5.6 ml, 40 mmol) were stirred at reflux under Ar for 24 h, and then evaporated to dryness. The residue was chromatographed on silica gel, eluting with dichloromethane/ethanol/ammonia (300:8:1). This gave the title compound (1.95 g, 58%) as a white solid.

1. temperatureat reflux under Ar for 24 h
2. customevaporated to dryness
3. customThe residue was chromatographed on silica gel
4. washeluting with dichloromethane/ethanol/ammonia (300:8:1)