Iodoethane → 1-Ethyl-1,2,3,6-tetrahydropyridine-4-methanol

HRID 1741086Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][OH:8])=[CH:3][CH:2]=1.I[CH2:10][CH3:11]>>[CH2:10]([N:1]1[CH2:6][CH:5]=[C:4]([CH2:7][OH:8])[CH2:3][CH2:2]1)[CH3:11]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 114724-Hydroxymethylpyridine

Product 1

HCID 218337641-Ethyl-1,2,3,6-tetrahydropyridine-4-methanol

Procedure

The title compound was prepared from 4-pyridylcarbinol and iodoethane following a similar procedure to that described for the 1-methyl analogue in J. Med. Chem., 1988, 31, 545(92%).

Sources & evidence

ORD record: ord-65c713a773ca4b079aeeb3088592ce7f
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972951

Reaction notes

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