1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → 5-(4'-(5-Dimethylamino-1,2,4-oxadiazol-3-yl)-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Participants

Reaction Steps

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] (D8) and 4'-(5-dimethylamino-1,2,4-oxadiazol-3-yl)-2'-methylbiphenyl-4-carboxylic acid (D14) using a procedure similar to that of Example 1 (18%). This was converted to the oxalate salt, which precipitated from acetone/ether as a white solid.

Provenance & Evidence