1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → 1'-Methyl-5-[4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

HRID 1741097Notes

Reaction equation

HRID 1741097 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][NH:15][C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1.[CH3:19][C:20]1[O:24][N:23]=[C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][C:34]([C:37](O)=[O:38])=[CH:33][CH:32]=3)=[CH:27][CH:26]=2)[N:21]=1>>[CH3:1][N:2]1[CH2:3][CH2:4][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][N:15]([C:37]([C:34]5[CH:33]=[CH:32][C:31]([C:28]6[CH:29]=[CH:30][C:25]([C:22]7[N:21]=[C:20]([CH3:19])[O:24][N:23]=7)=[CH:26][CH:27]=6)=[CH:36][CH:35]=5)=[O:38])[C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 218337574'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxylic acid

Product 1

HCID 218337921'-Methyl-5-[4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Procedure

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] (D8) and 4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid (D15), using a procedure similar to that of Example 1 (57%).

Sources & evidence

ORD record
ord-ed35fa5d8fc94c9284edd5dcd8f82519
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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