1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → 1'-Methyl-5-[4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Participants

Role	Name	HCID	Charge
Reactant	1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]	HCID 10657952	—
Reactant	4'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxylic acid	HCID 21833757	—
Product	1'-Methyl-5-[4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]	HCID 21833792	—

Reaction Steps

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] (D8) and 4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid (D15), using a procedure similar to that of Example 1 (57%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05972951
Source dataset	uspto-grants-1999_10
ORD ID	ord-ed35fa5d8fc94c9284edd5dcd8f82519
Source note	uspto-grants-1999_10