1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → 5-(4'-Acetyl-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

HRID 1741099Notes

Reaction equation

HRID 1741099 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][NH:15][C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1.[C:19]([C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34](O)=[O:35])=[CH:30][CH:29]=2)=[C:24]([CH3:37])[CH:23]=1)(=[O:21])[CH3:20]>>[C:19]([C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([N:15]3[C:16]4[CH:17]=[C:18]5[C:5]6([CH2:8][O:9][C:10]5=[CH:11][C:12]=4[CH2:13][CH2:14]3)[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]6)=[O:35])=[CH:30][CH:29]=2)=[C:24]([CH3:37])[CH:23]=1)(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 218337394'-Acetyl-2'-methyl-[1,1'-biphenyl]-4-carboxylic acid

Product 1

HCID 218337795-(4'-Acetyl-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Procedure

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (D8) and 4'-acetyl-2'-methylbiphenyl-4-carboxylic acid (D19) using a procedure similar to that of Example 1 (35%).

Sources & evidence

ORD record
ord-df53e810f6b24c9e966c61e0f1fd9a62
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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