1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → 5-(5'-Methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

HRID 1741107Notes

Reaction equation

HRID 1741107 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:18]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][NH:15][C:16]=4[CH:17]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1.[CH3:19][O:20][C:21]([C:23]1[CH:24]=[CH:25][C:26]([CH3:38])=[C:27]([C:29]2[CH:34]=[CH:33][C:32]([C:35](O)=[O:36])=[CH:31][CH:30]=2)[CH:28]=1)=[O:22]>>[CH3:19][O:20][C:21]([C:23]1[CH:24]=[CH:25][C:26]([CH3:38])=[C:27]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([N:15]3[C:16]4[CH:17]=[C:18]5[C:5]6([CH2:8][O:9][C:10]5=[CH:11][C:12]=4[CH2:13][CH2:14]3)[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]6)=[O:36])=[CH:31][CH:30]=2)[CH:28]=1)=[O:22]

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 218337563-Methyl 6-methyl[1,1′-biphenyl]-3,4′-dicarboxylate

Product 1

HCID 218337485-(5'-Methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Procedure

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] (D8) and 5'-methoxycarbonyl-2'-methylbiphenyl-4-carboxylic acid (D42) using a similar procedure to Example 1 (51%).

Sources & evidence

ORD record
ord-8925e1e8fc1b4adc9cf104157f585697
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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