1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → 5-(5'-Methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]

Participants

Role	Name	HCID	Charge
Reactant	1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]	HCID 10657952	—
Reactant	3-Methyl 6-methyl[1,1′-biphenyl]-3,4′-dicarboxylate	HCID 21833756	—
Product	5-(5'-Methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]	HCID 21833748	—

Reaction Steps

The title compound was prepared from 1'-methyl-2,3,6,7-tetrahydrospiro [furo[2,3-f]indole-3,4'-piperidine] (D8) and 5'-methoxycarbonyl-2'-methylbiphenyl-4-carboxylic acid (D42) using a similar procedure to Example 1 (51%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05972951
Source dataset	uspto-grants-1999_10
ORD ID	ord-8925e1e8fc1b4adc9cf104157f585697
Source note	uspto-grants-1999_10