HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 5-(4'-Acetamido-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] | HCID 10657952 | — |
| Reactant | 4'-Acetamido-2'-methylbiphenyl-4-carboxylic acid | HCID 18694263 | — |
| Product | 5-(4'-Acetamido-2'-methylbiphenyl-4-carbonyl)-1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] | HCID 18694300 | — |
Reaction Steps
The title compound was prepared from 4'-acetamido-2'-methylbiphenyl-4-carboxylic acid (D47) and 1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (D8) following a similar procedure to Example 1 using oxalyl chloride in place of thionyl chloride, as a yellow oil (43%). This was converted to its oxalate salt which crystallised as a white solid from acetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05972951 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-7cea0fa5fa8f444399c308802ec33428 |
| Source note | uspto-grants-1999_10 |