HRID1741110

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID65578

Ethanedioyl dichloride

C2Cl2O2

HCID10657952

未命名化合物

结构：CC(=O)Nc1ccc(-c2ccc(C(=O)O)cc2)c(C)c1

HCID18694263

4'-Acetamido-2'-methyl[1,1'-biphenyl]-4-carboxylic acid

C16H15NO3

PRODUCTS

生成物

结构：CC(=O)Nc1ccc(-c2ccc(C(=O)N3CCc4cc5c(cc43)C3(CCN(C)CC3)CO5)cc2)c(C)c1

HCID18694300

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4'-acetamido-2'-methylbiphenyl-4-carboxylic acid (D47) and 1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (D8) following a similar procedure to Example 1 using oxalyl chloride in place of thionyl chloride, as a yellow oil (43%). This was converted to its oxalate salt which crystallised as a white solid from acetone.

WORKUP

后处理

customcrystallised as a white solid from acetone

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7cea0fa5fa8f444399c308802ec33428
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05972951
来源说明: uspto-grants-1999_10

反应 SMILES

[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([OH:19])=O)=[CH:13][CH:12]=2)=[C:7]([CH3:20])[CH:6]=1)(=[O:3])[CH3:2].[CH3:21][N:22]1[CH2:27][CH2:26][C:25]2([C:38]3[C:30](=[CH:31][C:32]4[CH2:33][CH2:34][NH:35][C:36]=4[CH:37]=3)[O:29][CH2:28]2)[CH2:24][CH2:23]1.C(Cl)(=O)C(Cl)=O>>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]([C:17]([N:35]3[C:36]4[CH:37]=[C:38]5[C:25]6([CH2:28][O:29][C:30]5=[CH:31][C:32]=4[CH2:33][CH2:34]3)[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]6)=[O:19])=[CH:15][CH:16]=2)=[C:7]([CH3:20])[CH:6]=1)(=[O:3])[CH3:2]