4'-(Methoxycarbonyl)-2'-methyl-[1,1'-biphenyl]-4-carboxylic acid → 2,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro [furo[2,3-g]quinoline-3,4'-piperidine]

HRID 1741118Notes

Reaction equation

HRID 1741118 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:19]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][CH2:15][NH:16][C:17]=4[CH:18]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1.[CH3:20][O:21][C:22]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36](O)=[O:37])=[CH:32][CH:31]=2)=[C:26]([CH3:39])[CH:25]=1)=[O:23]>>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:19]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][CH2:15][N:16]([C:36]([C:33]5[CH:34]=[CH:35][C:30]([C:27]6[CH:28]=[CH:29][C:24]([C:22]([O:21][CH3:20])=[O:23])=[CH:25][C:26]=6[CH3:39])=[CH:31][CH:32]=5)=[O:37])[C:17]=4[CH:18]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 218337994'-(Methoxycarbonyl)-2'-methyl-[1,1'-biphenyl]-4-carboxylic acidHCID 221158852,3,5,6,7,8-Hexahydro-1'-methylspiro[furo[2,3-g]quinoline-3,4'-piperidine]

Product 1

HCID 218337292,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro [furo[2,3-g]quinoline-3,4'-piperidine]

Procedure

The title compound was prepared from 2,3,5,6,7,8-hexahydro-1'-methylspiro[furo[2,3-g]quinoline-3,4'-piperidine] (D10) and 4'-methoxycarbonyl-2'-methylbiphenyl-4-carboxylic acid (D41) using a procedure similar to that of Example 1 (46%).

Sources & evidence

ORD record
ord-6fcacae68b9d4c6c8a0e6314fa9b43df
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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