4'-(Methoxycarbonyl)-2'-methyl-[1,1'-biphenyl]-4-carboxylic acid → 2,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro [furo[2,3-g]quinoline-3,4'-piperidine]

Participants

Role	Name	HCID	Charge
Reactant	4'-(Methoxycarbonyl)-2'-methyl-[1,1'-biphenyl]-4-carboxylic acid	HCID 21833799	—
Reactant	2,3,5,6,7,8-Hexahydro-1'-methylspiro[furo[2,3-g]quinoline-3,4'-piperidine]	HCID 22115885	—
Product	2,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro [furo[2,3-g]quinoline-3,4'-piperidine]	HCID 21833729	—

Reaction Steps

The title compound was prepared from 2,3,5,6,7,8-hexahydro-1'-methylspiro[furo[2,3-g]quinoline-3,4'-piperidine] (D10) and 4'-methoxycarbonyl-2'-methylbiphenyl-4-carboxylic acid (D41) using a procedure similar to that of Example 1 (46%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05972951
Source dataset	uspto-grants-1999_10
ORD ID	ord-6fcacae68b9d4c6c8a0e6314fa9b43df
Source note	uspto-grants-1999_10