Hydrazine hydrate (1:1) → 2,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-hydrazinocarbonyl-2'-methylbiphenyl-4-carbonyl)spiro[furo[2,3-g]quinoline-3,4'-piperidine]

Participants

Role	Name	HCID	Charge
Reactant	Hydrazine hydrate (1:1)	HCID 24654	—
Reactant	2,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro [furo[2,3-g]quinoline-3,4'-piperidine]	HCID 21833729	—
Product	2,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-hydrazinocarbonyl-2'-methylbiphenyl-4-carbonyl)spiro[furo[2,3-g]quinoline-3,4'-piperidine]	HCID 21833749	—

Reaction Steps

The title compound was prepared from 2,3,5,6,7,8-hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro[furo[2,3-g]quinoline-3,4'-piperidine] (E48) and hydrazine monohydrate, using a procedure similar to that of Example 25 (90%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05972951
Source dataset	uspto-grants-1999_10
ORD ID	ord-0b5645461f894b75b86d1871aa6e513b
Source note	uspto-grants-1999_10