Hydrazine hydrate (1:1) → 2,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-hydrazinocarbonyl-2'-methylbiphenyl-4-carbonyl)spiro[furo[2,3-g]quinoline-3,4'-piperidine]

HRID 1741119Notes

Reaction equation

HRID 1741119 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:19]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][CH2:15][N:16]([C:20]([C:22]5[CH:27]=[CH:26][C:25]([C:28]6[CH:33]=[CH:32][C:31]([C:34]([O:36]C)=O)=[CH:30][C:29]=6[CH3:38])=[CH:24][CH:23]=5)=[O:21])[C:17]=4[CH:18]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1.O.[NH2:40][NH2:41]>>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2([C:19]3[C:10](=[CH:11][C:12]4[CH2:13][CH2:14][CH2:15][N:16]([C:20]([C:22]5[CH:23]=[CH:24][C:25]([C:28]6[CH:33]=[CH:32][C:31]([C:34]([NH:40][NH2:41])=[O:36])=[CH:30][C:29]=6[CH3:38])=[CH:26][CH:27]=5)=[O:21])[C:17]=4[CH:18]=3)[O:9][CH2:8]2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 218337292,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro [furo[2,3-g]quinoline-3,4'-piperidine]

Product 1

HCID 218337492,3,5,6,7,8-Hexahydro-1'-methyl-5-(4'-hydrazinocarbonyl-2'-methylbiphenyl-4-carbonyl)spiro[furo[2,3-g]quinoline-3,4'-piperidine]

Procedure

The title compound was prepared from 2,3,5,6,7,8-hexahydro-1'-methyl-5-(4'-methoxycarbonyl-2'-methylbiphenyl-4-carbonyl)spiro[furo[2,3-g]quinoline-3,4'-piperidine] (E48) and hydrazine monohydrate, using a procedure similar to that of Example 25 (90%).

Sources & evidence

ORD record
ord-0b5645461f894b75b86d1871aa6e513b
Source dataset
uspto-grants-1999_10
Patent number
US05972951

Reaction notes

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