m-Chloroperbenzoic acid → HCID 18707473, compound

HRID 1741156Notes

Reaction equation

HRID 1741156 reaction equation
[CH3:1][S:2][C:3]1[S:4][C:5]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=2)=[N:6][N:7]=1.ClC1C=C(C=CC=1)C(OO)=[O:23]>ClCCl>[CH3:1][S:2]([C:3]1[S:4][C:5]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=2)=[N:6][N:7]=1)=[O:23]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 18707479HCID 18707479, compound

Product 1

HCID 18707473HCID 18707473, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of 2-methylsulfanyl-5-naphthalen-2-yl-[1,3,4]thiadiazole (1.3 g, 5.03 mmol) in dichloromethane (50 ml) was added 50% moisten 3-chloro peroxybenzoic acid (1.9 g, 5.53 mmol) at 0° C. After stirred for 1 h at 0° C. the reaction was diluted with dichloromethane (50 ml) and quenched with addition of saturated aqueous sodium hydrogen carbonate (50 ml). The organic phase was separated and washed with. water (50 ml), dried (MgSO4), filtered and evaporated in vacuo. The residue (1.4 g) was purified by column chromatography on silicagel (400 ml) using a mixture of ethyl acetate and heptane (1:1) as eluent. This afforded after drying in vacuo at 50° C. 0.9 g (65%) of the title compound as a solid.

Workup

  1. customquenched with addition of saturated aqueous sodium hydrogen carbonate (50 ml)
  2. customThe organic phase was separated
  3. washwashed with
  4. dry with materialwater (50 ml), dried (MgSO4)
  5. filtrationfiltered
  6. customevaporated in vacuo
  7. customThe residue (1.4 g) was purified by column chromatography on silicagel (400 ml)
  8. additiona mixture of ethyl acetate and heptane (1:1) as eluent
  9. customThis afforded
  10. customafter drying in vacuo at 50° C

Sources & evidence

ORD record
ord-01777060e0ee41f5a25c55a2bb14686f
Source dataset
uspto-grants-1999_10
Patent number
US05972978

Reaction notes

Loading…