Triphenylphosphine → HCID 86751809, compound

HRID 1741314Notes

Reaction equation

[F:1][C:2]([F:23])([F:22])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:17][O:18][CH2:19][CH2:20][OH:21])[CH3:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.O[C:25]1[CH:57]=[CH:56][C:28]([CH2:29][CH:30]2[S:34][C:33](=[O:35])[N:32]([C:36]([C:49]3[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=3)([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:31]2=[O:55])=[CH:27][CH:26]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>>[F:1][C:2]([F:22])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:17][O:18][CH2:19][CH2:20][O:21][C:25]3[CH:57]=[CH:56][C:28]([CH2:29][CH:30]4[S:34][C:33](=[O:35])[N:32]([C:36]([C:49]5[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=5)([C:43]5[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=5)[C:37]5[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=5)[C:31]4=[O:55])=[CH:27][CH:26]=3)[CH3:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

Reactant 4

HCID 11776Triphenylphosphine

HCID 220568ethyl N-ethoxycarbonyliminocarbamate

HCID 28181265-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione

HCID 54338999HCID 54338999, compound

Product 1

HCID 86751809HCID 86751809, compoundYield 87.6%

Procedure

Following a procedure similar to that described in Example 1(a), but using 647 mg of 2-[1-(4'-trifluoromethylbiphenyl-4-yl)ethylideneaminooxy]ethanol (prepared as described in Preparation 28), 931 mg of 5-(4-hydroxybenzyl)-3-tritylthiazolidine-2,4-dione, 577 mg of triphenylphosphine and 366 mg of diethyl azodicarboxylate, 1.35 g of the title compound were obtained as a foam-like solid.

Sources & evidence

ORD record: ord-1d7fc3dbef2a4beda9f09bbe169a612b
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972959

Reaction notes

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