Triphenylphosphine → HCID 86751812, compound

HRID 1741318Notes

Reaction equation

[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[N:13][O:14][CH2:15][CH2:16][OH:17])[CH3:12])=[CH:7][N:6]=1)([CH3:3])[CH3:2].O[C:19]1[CH:51]=[CH:50][C:22]([CH2:23][CH:24]2[S:28][C:27](=[O:29])[N:26]([C:30]([C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]2=[O:49])=[CH:21][CH:20]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[N:13][O:14][CH2:15][CH2:16][O:17][C:19]2[CH:51]=[CH:50][C:22]([CH2:23][CH:24]3[S:28][C:27](=[O:29])[N:26]([C:30]([C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[C:25]3=[O:49])=[CH:21][CH:20]=2)[CH3:12])=[CH:7][N:6]=1)([CH3:2])[CH3:3]

Participants

Reactant 4

HCID 11776Triphenylphosphine

HCID 220568ethyl N-ethoxycarbonyliminocarbamate

HCID 28181265-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione

HCID 53876084HCID 53876084, compound

Product 1

HCID 86751812HCID 86751812, compoundYield 81.4%

Procedure

Following a procedure similar to that described in Example 1(a), but using 1.02 g of 2-[1-(2-isopropoxy-5-pyridyl)ethylideneaminooxy]ethanol (prepared as described in Preparation 32), 2.00 g of 5-(4-hydroxybenzyl)-3-tritylthiazolidine-2,4-dione, 1.24 g of triphenylphosphine and 784 mg of diethyl azodicarboxylate, 2.39 g of the title compound were obtained as a foam-like solid.

Sources & evidence

ORD record: ord-83fc5a9b35934c93b462f6351e8363b5
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05972959

Reaction notes

Loading…