Sodium Hydroxide → HCID 86754722, compound

HRID 1741372Notes

Reaction equation

HRID 1741372 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH:18]3[CH:22]([CH2:23][C:24]4[CH:25]=[C:26]([CH:34]=[CH:35][CH:36]=4)[O:27][CH2:28][C:29]([O:31]CC)=[O:30])[CH2:21][CH2:20][O:19]3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:38]>C(O)C>[C:1]1([C:7]2[N:8]=[C:9]([CH:18]3[CH:22]([CH2:23][C:24]4[CH:25]=[C:26]([CH:34]=[CH:35][CH:36]=4)[O:27][CH2:28][C:29]([O-:31])=[O:30])[CH2:21][CH2:20][O:19]3)[O:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[Na+:38]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54314668HCID 54314668, compound

Product 1

HCID 86754722HCID 86754722, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl [3-[[2-(4,5-diphenyloxazol-2-yl)tetrahydrofuran-3-yl]methyl]phenoxy]acetate (560 mg) in ethanol (20 ml) was added 1N-NaOH solution (1.2 ml). After being stirred for 4 hours at the same temperature, the solvent was removed in vacuo to give sodium [3-[[2-(4,5-diphenyloxazol-2-yl)tetrahydrofuran-3-yl]methyl]phenoxy]-acetate (0.46 g) FABMS (m/z): 478 (M+ +1) IR (Nujol): 3400, 1600 cm-1NMR (DMSO-d6, δ): 1.6-3.0 (5H, m), 3.8-4.2 (4H, m), 4.68 (1/3H, d, J=7.0 Hz), 5.13 (2/3H, d, J=8.0 Hz), 6.6-6.8 (3H, m), 7.0 (1H, t, J=8 Hz), 7.2-7.8 (10H, m)

Workup

  1. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-7195421a0b5447c1b5da1a2f3234270c
Source dataset
uspto-grants-1999_10
Patent number
US05972965

Reaction notes

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