反应详情

9.05 (45.6 mnol) of 1-chloro-3-(3,4-dimethylphenoxy)- propane obtained in step 1 was dissolved in 200 ml of toluene. To the resulting solution were added 14.8 g of NaN3, 2.9 g of n-Bu4NBr and 15.2 g of KI and the mixture was refluxed For 24 hours. The reaction mixture was washed with water and concentrated under a reduced pressure. The resulting residue was purified by chromatography (ethyl acetate: hexane=1:10) to obtain 9.04 g (yield 97%) of the title compound as a brown oil.

1. temperaturethe mixture was refluxed For 24 hours
2. washThe reaction mixture was washed with water
3. concentrationconcentrated under a reduced pressure
4. customThe resulting residue was purified by chromatography (ethyl acetate: hexane=1:10)