Chlorpheniramine Maleate → Chlorpheniramine

HRID 1741557Notes

Reaction equation

HRID 1741557 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH:6]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][N:19]=1)[C:7]1[CH:8]=[CH:9][C:10]([Cl:13])=[CH:11][CH:12]=1)[CH3:3].C(/C(O)=O)=C/C(O)=O>O>[CH3:1][N:2]([CH2:4][CH2:5][CH:6]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][N:19]=1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)[CH3:3]

Participants

3

Reactant 1

HCID 5281068Chlorpheniramine Maleate

Product 1

HCID 2725Chlorpheniramine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

86.0 g of chlorpheniramine maleate was dissolved in 1634.0 ml of deionized water. While stirring, 200.0 g of Amberlite® IRP-69 was added thereto and the mixture was stirred for 30 minutes. The resultant complex was collected on a buchner funnel and washed thoroughly, and then dried in a fluidized bed drier at an inlet air temperature of 60° C. for 1 hour to yield (chlorpheniramine)-(ion exchange resin) complex.

Workup

  1. addition200.0 g of Amberlite® IRP-69 was added
  2. stirringthe mixture was stirred for 30 minutes
  3. customThe resultant complex was collected on a buchner funnel
  4. washwashed thoroughly
  5. customdried in a fluidized bed drier at an inlet air temperature of 60° C. for 1 hour

Sources & evidence

ORD record
ord-b76187ff6a3341c393a28e3ccad5d08a
Source dataset
uspto-grants-1994_08
Patent number
US05334378

Reaction notes

Loading…